7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands

A series of N-benzyl-7-azaindolequinuclidinone (7-AIQD) analogs have been synthesized and evaluated for affinity toward CB1 and CB2 cannabinoid receptors and identified as a novel class of cannabinoid receptor ligands. Structure–activity relationship (SAR) studies indicate that 7-AIQD analogs are du...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Penthala, Narsimha Reddy, Shoeib, Amal M., Dachavaram, Soma Shekar, Cabanlong, Christian V., Yang, Jingfang, Zhan, Chang-Guo, Prather, Paul L., Crooks, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686103/
https://ncbi.nlm.nih.gov/pubmed/32882418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127501
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