Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor

Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB(2) receptor. These compounds selectively target CB(2) versus CB(...

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發表在:Chemistry
Main Authors: Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756656/
https://ncbi.nlm.nih.gov/pubmed/32794211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003389
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