Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor

Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB(2) receptor. These compounds selectively target CB(2) versus CB(...

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Bibliographic Details
Published in:Chemistry
Main Authors: Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756656/
https://ncbi.nlm.nih.gov/pubmed/32794211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003389
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