Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits

Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human constitutive proteasomes an...

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Sparad:
Bibliografiska uppgifter
I publikationen:Chembiochem
Huvudupphovsmän: Maurits, Elmer, Degeling, Christian G., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754458/
https://ncbi.nlm.nih.gov/pubmed/32598532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000375
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