Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

Proteasomes degrade the majority of proteins in mammalian cells, are involved in the regulation of multiple physiological functions, and are established targets of anti-cancer drugs. The proteasome has three types of active sites. Chymotrypsin-like sites are the most important for protein breakdown...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Mirabella, Anne C., Pletnev, Alexandre A., Downey, Sondra L., Florea, Bogdan I., Shabaneh, Tamer B., Britton, Matthew, Verdoes, Martijn, Filippov, Dmitri V., Overkleeft, Herman S., Kisselev, Alexei F.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134264/
https://ncbi.nlm.nih.gov/pubmed/21609842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.02.015
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares