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Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib
Proteasomes degrade the majority of proteins in mammalian cells, are involved in the regulation of multiple physiological functions, and are established targets of anti-cancer drugs. The proteasome has three types of active sites. Chymotrypsin-like sites are the most important for protein breakdown...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134264/ https://ncbi.nlm.nih.gov/pubmed/21609842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.02.015 |
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