Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance

HIV protease inhibitors (HIV-PI) are oral drugs for HIV treatment. HIV-PI have antitumor activity via induction of ER-stress, inhibition of phospho-AKT (p-AKT) and the proteasome, suggesting antimyeloma activity. We characterize the effects of all approved HIV-PI on myeloma cells. HIV-PI were compar...

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Autors principals: Kraus, M, Bader, J, Overkleeft, H, Driessen, C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615215/
https://ncbi.nlm.nih.gov/pubmed/23454896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.2
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