Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro. We determined dose-limiting toxicity and recommended dose for phase II of nelf...

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Publié dans:Haematologica
Auteurs principaux: Driessen, Christoph, Kraus, Marianne, Joerger, Markus, Rosing, Hilde, Bader, Jürgen, Hitz, Felicitas, Berset, Catherine, Xyrafas, Alexandros, Hawle, Hanne, Berthod, Gregoire, Overkleeft, Hermann S., Sessa, Christiana, Huitema, Alwin, Pabst, Thomas, von Moos, Roger, Hess, Dagmar, Mey, Ulrich J.M.
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815726/
https://ncbi.nlm.nih.gov/pubmed/26659919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.135780
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