Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

Proteasomes degrade the majority of proteins in mammalian cells, are involved in the regulation of multiple physiological functions, and are established targets of anti-cancer drugs. The proteasome has three types of active sites. Chymotrypsin-like sites are the most important for protein breakdown...

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Detaylı Bibliyografya
Asıl Yazarlar: Mirabella, Anne C., Pletnev, Alexandre A., Downey, Sondra L., Florea, Bogdan I., Shabaneh, Tamer B., Britton, Matthew, Verdoes, Martijn, Filippov, Dmitri V., Overkleeft, Herman S., Kisselev, Alexei F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134264/
https://ncbi.nlm.nih.gov/pubmed/21609842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.02.015
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