Canagliflozin extends life span in genetically heterogeneous male but not female mice

Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the mouse Interventions Testing Program, genetically he...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Miller, Richard A., Harrison, David E., Allison, David B., Bogue, Molly, Debarba, Lucas, Diaz, Vivian, Fernandez, Elizabeth, Galecki, Andrzej, Garvey, W. Timothy, Jayarathne, Hashan, Kumar, Navasuja, Javors, Martin A., Ladiges, Warren C., Macchiarini, Francesca, Nelson, James, Reifsnyder, Peter, Rosenthal, Nadia A., Sadagurski, Marianna, Salmon, Adam B., Smith, Daniel L., Snyder, Jessica M., Lombard, David B., Strong, Randy
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710304/
https://ncbi.nlm.nih.gov/pubmed/32990681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140019
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