Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Strong, Randy, Miller, Richard A., Bogue, Molly, Fernandez, Elizabeth, Javors, Martin A., Libert, Sergiy, Marinez, Paul Anthony, Murphy, Michael P., Musi, Nicolas, Nelson, James F., Petrascheck, Michael, Reifsnyder, Peter, Richardson, Arlan, Salmon, Adam B., Macchiarini, Francesca, Harrison, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681050/
https://ncbi.nlm.nih.gov/pubmed/33145977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13269
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