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Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

Previous studies have shown that inducing autophagy ameliorates early cognitive deficits associated with the build-up of soluble amyloid-β (Aβ). However, the effects of inducing autophagy on plaques and tangles are yet to be determined. While soluble Aβ and tau represent toxic species in Alzheimer&#...

詳細記述

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書誌詳細
主要な著者: Majumder, Smita, Richardson, Arlan, Strong, Randy, Oddo, Salvatore
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182203/
https://ncbi.nlm.nih.gov/pubmed/21980451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025416
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