Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. However, whether hyperactive mTOR plays a role in the cognitive deficits associated with AD remains elusive. Here, we g...

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Detalhes bibliográficos
Main Authors: Caccamo, Antonella, De Pinto, Vito, Messina, Angela, Branca, Caterina, Oddo, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044255/
https://ncbi.nlm.nih.gov/pubmed/24899720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0777-14.2014
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