CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

Cognitive dysfunction and memory loss are common features of Alzheimer's disease (AD). Abnormalities in the expression profile of immediate early genes that play a critical role in memory formation, such as the cAMP-response element binding protein (CREB), have been reported in the brains of AD...

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Hauptverfasser: Caccamo, Antonella, Maldonado, Monica A., Bokov, Alex F., Majumder, Smita, Oddo, Salvatore
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012497/
https://ncbi.nlm.nih.gov/pubmed/21149712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012851108
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