Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

BACKGROUND: Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that long-term treatment with rapamycin, an inhibitor of the mTOR pathway[5], or ablation of the mTOR target p70S6K[6] extends lifespan in mi...

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Detalhes bibliográficos
Main Authors: Spilman, Patricia, Podlutskaya, Natalia, Hart, Matthew J., Debnath, Jayanta, Gorostiza, Olivia, Bredesen, Dale, Richardson, Arlan, Strong, Randy, Galvan, Veronica
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848616/
https://ncbi.nlm.nih.gov/pubmed/20376313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009979
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