Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longe...

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Detalhes bibliográficos
Main Authors: Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., Richardson, Arlan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883653/
https://ncbi.nlm.nih.gov/pubmed/24409289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083988
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