Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longe...

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Bibliographic Details
Main Authors: Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., Richardson, Arlan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883653/
https://ncbi.nlm.nih.gov/pubmed/24409289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083988
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