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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit flies1–5. However, whether inhibition of mTOR signalling can extend life in a mammalian species was unknown. We report here that rapamycin, an i...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786175/ https://ncbi.nlm.nih.gov/pubmed/19587680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08221 |
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