Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Miller, Richard A, Harrison, David E, Astle, Clinton M, Fernandez, Elizabeth, Flurkey, Kevin, Han, Melissa, Javors, Martin A, Li, Xinna, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Salmon, Adam B, Sharp, Zelton Dave, Van Roekel, Sabrina, Winkleman, Lynn, Strong, Randy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BlackWell Publishing Ltd 2014
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
https://ncbi.nlm.nih.gov/pubmed/24341993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12194
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