Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in...

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Detalhes bibliográficos
Main Authors: Miller, Richard A, Harrison, David E, Astle, Clinton M, Fernandez, Elizabeth, Flurkey, Kevin, Han, Melissa, Javors, Martin A, Li, Xinna, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Salmon, Adam B, Sharp, Zelton Dave, Van Roekel, Sabrina, Winkleman, Lynn, Strong, Randy
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
https://ncbi.nlm.nih.gov/pubmed/24341993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12194
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