Rapamycin extends life span in Apc(Min/+) colon cancer FAP model

MICRO: Rapamycin extends life and health span in wild type mice suggesting prevention of cancer. We show rapamycin extends survival in colon cancer prone mice and that crypt cells are primary targets of mTOR inhibition that mediate tumor prevention or delay. STRUCTURED: We previously showed that lif...

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Veröffentlicht in:Clin Colorectal Cancer
Hauptverfasser: Parihar, Manish, Dodds, Sherry G., Hubbard, Gene, Javors, Marty, Strong, Randy, Hasty, Paul, Sharp, Zelton Dave
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956131/
https://ncbi.nlm.nih.gov/pubmed/33132009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clcc.2020.08.006
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