Rapamycin extends life span of Rb1(+/−) mice by inhibiting neuroendocrine tumors

Chronic treatment of mice with an enterically released formulation of rapamycin (eRapa) extends median and maximum life span, partly by attenuating cancer. The mechanistic basis of this response is not known. To gain a better understanding of these in vivo effects, we used a defined preclinical mode...

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Detalhes bibliográficos
Main Authors: Livi, Carolina B., Hardman, Rulon L., Christy, Barbara A., Dodds, Sherry G., Jones, Diane, Williams, Charnae, Strong, Randy, Bokov, Alex, Javors, Martin A., Ikeno, Yuji, Hubbard, Gene, Hasty, Paul, Sharp, Zelton Dave
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616197/
https://ncbi.nlm.nih.gov/pubmed/23454836
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