p53 and rapamycin are additive

Mechanistic target of rapamycin (mTOR) is a kinase found in a complex (mTORC1) that enables macromolecular synthesis and cell growth and is implicated in cancer etiology. The rapamycin-FK506 binding protein 12 (FKBP12) complex allosterically inhibits mTORC1. In response to stress, p53 inhibits mTORC...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Christy, Barbara, Demaria, Marco, Campisi, Judith, Huang, Jing, Jones, Diane, Dodds, Sherry G., Williams, Charnae, Hubbard, Gene, Livi, Carolina B., Gao, Xiaoli, Weintraub, Susan, Curiel, Tyler, Sharp, Z. Dave, Hasty, Paul
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599238/
https://ncbi.nlm.nih.gov/pubmed/26158292
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