Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit flies1–5. However, whether inhibition of mTOR signalling can extend life in a mammalian species was unknown. We report here that rapamycin, an i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Harrison, David E., Strong, Randy, Sharp, Zelton Dave, Nelson, James F., Astle, Clinton M., Flurkey, Kevin, Nadon, Nancy L., Wilkinson, J. Erby, Frenkel, Krystyna, Carter, Christy S., Pahor, Marco, Javors, Martin A., Fernandez, Elizabeth, Miller, Richard A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786175/
https://ncbi.nlm.nih.gov/pubmed/19587680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08221
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg