Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB) — were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lif...

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Main Authors: Harrison, David E, Strong, Randy, Allison, David B, Ames, Bruce N, Astle, Clinton M, Atamna, Hani, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Simpkins, James W, Smith, Daniel, Wilkinson, J Erby, Miller, Richard A
格式: Artigo
語言:Inglês
出版: BlackWell Publishing Ltd 2014
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954939/
https://ncbi.nlm.nih.gov/pubmed/24245565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12170
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