Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB) — were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lif...

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Hlavní autoři: Harrison, David E, Strong, Randy, Allison, David B, Ames, Bruce N, Astle, Clinton M, Atamna, Hani, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Simpkins, James W, Smith, Daniel, Wilkinson, J Erby, Miller, Richard A
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954939/
https://ncbi.nlm.nih.gov/pubmed/24245565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12170
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