Acarbose improves health and lifespan in aging HET3 mice

To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Harrison, David E., Strong, Randy, Alavez, Silvestre, Astle, Clinton Michael, DiGiovanni, John, Fernandez, Elizabeth, Flurkey, Kevin, Garratt, Michael, Gelfond, Jonathan A. L., Javors, Martin A., Levi, Moshe, Lithgow, Gordon J., Macchiarini, Francesca, Nelson, James F., Sukoff Rizzo, Stacey J., Slaga, Thomas J., Stearns, Tim, Wilkinson, John Erby, Miller, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413665/
https://ncbi.nlm.nih.gov/pubmed/30688027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12898
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