Acarbose improves health and lifespan in aging HET3 mice

To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change...

詳細記述

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書誌詳細
出版年:Aging Cell
主要な著者: Harrison, David E., Strong, Randy, Alavez, Silvestre, Astle, Clinton Michael, DiGiovanni, John, Fernandez, Elizabeth, Flurkey, Kevin, Garratt, Michael, Gelfond, Jonathan A. L., Javors, Martin A., Levi, Moshe, Lithgow, Gordon J., Macchiarini, Francesca, Nelson, James F., Sukoff Rizzo, Stacey J., Slaga, Thomas J., Stearns, Tim, Wilkinson, John Erby, Miller, Richard A.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
Original Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413665/
https://ncbi.nlm.nih.gov/pubmed/30688027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12898
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