Acarbose improves health and lifespan in aging HET3 mice

To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change...

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Detaylı Bibliyografya
Yayımlandı:Aging Cell
Asıl Yazarlar: Harrison, David E., Strong, Randy, Alavez, Silvestre, Astle, Clinton Michael, DiGiovanni, John, Fernandez, Elizabeth, Flurkey, Kevin, Garratt, Michael, Gelfond, Jonathan A. L., Javors, Martin A., Levi, Moshe, Lithgow, Gordon J., Macchiarini, Francesca, Nelson, James F., Sukoff Rizzo, Stacey J., Slaga, Thomas J., Stearns, Tim, Wilkinson, John Erby, Miller, Richard A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413665/
https://ncbi.nlm.nih.gov/pubmed/30688027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12898
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