Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Four agents — acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB) — were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lif...

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Detalhes bibliográficos
Main Authors: Harrison, David E, Strong, Randy, Allison, David B, Ames, Bruce N, Astle, Clinton M, Atamna, Hani, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Simpkins, James W, Smith, Daniel, Wilkinson, J Erby, Miller, Richard A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954939/
https://ncbi.nlm.nih.gov/pubmed/24245565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12170
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