Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and...

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Detalhes bibliográficos
Main Authors: Fok, Wilson C, Bokov, Alex, Gelfond, Jonathan, Yu, Zhen, Zhang, Yiqiang, Doderer, Mark, Chen, Yidong, Javors, Martin, Wood, William H, Zhang, Yongqing, Becker, Kevin G, Richardson, Arlan, Pérez, Viviana I
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989927/
https://ncbi.nlm.nih.gov/pubmed/24304444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12175
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