17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log‐rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 months, respectively. 90th percentile li...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Harrison, David E., Strong, Randy, Reifsnyder, Peter, Kumar, Navasuja, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A., Lopez‐Cruzan, Marisa, Macchiarini, Francesca, Nelson, James F., Markewych, Adrian, Bitto, Alessandro, Sindler, Amy L., Cortopassi, Gino, Kavanagh, Kylie, Leng, Lin, Bucala, Richard, Rosenthal, Nadia, Salmon, Adam, Stearns, Timothy M., Bogue, Molly, Miller, Richard A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135004/
https://ncbi.nlm.nih.gov/pubmed/33788371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13328
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