17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log‐rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 months, respectively. 90th percentile li...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Harrison, David E., Strong, Randy, Reifsnyder, Peter, Kumar, Navasuja, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A., Lopez‐Cruzan, Marisa, Macchiarini, Francesca, Nelson, James F., Markewych, Adrian, Bitto, Alessandro, Sindler, Amy L., Cortopassi, Gino, Kavanagh, Kylie, Leng, Lin, Bucala, Richard, Rosenthal, Nadia, Salmon, Adam, Stearns, Timothy M., Bogue, Molly, Miller, Richard A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2021
Ämnen:
Original Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135004/
https://ncbi.nlm.nih.gov/pubmed/33788371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13328
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk