Evolution of genomic and T cell repertoire heterogeneity of malignant pleural mesothelioma under dasatinib treatment

PURPOSE: Malignant pleural mesothelioma (MPM) is considered an orphan disease with few treatment options. Despite multimodality therapy, the majority of MPM recur and eventually become refractory to any systemic treatment. One potential mechanism underlying therapeutic resistance may be intratumor h...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Chen, Runzhe, Lee, Won-Chul, Fujimoto, Junya, Li, Jun, Hu, Xin, Mehran, Reza, Rice, David, Swisher, Stephen, Sepesi, Boris, Tran, Hai, Chow, Chi-Wan, Little, Latasha, Gumbs, Curtis, Haymaker, Cara, Heymach, John, Wistuba, Ignacio, Lee, J. Jack, Futreal, P. Andrew, Zhang, Jianhua, Reuben, Alexandre, Tsao, Anne, Zhang, Jianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709879/
https://ncbi.nlm.nih.gov/pubmed/32816946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1767
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