Evolution of genomic and T cell repertoire heterogeneity of malignant pleural mesothelioma under dasatinib treatment

PURPOSE: Malignant pleural mesothelioma (MPM) is considered an orphan disease with few treatment options. Despite multimodality therapy, the majority of MPM recur and eventually become refractory to any systemic treatment. One potential mechanism underlying therapeutic resistance may be intratumor h...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Chen, Runzhe, Lee, Won-Chul, Fujimoto, Junya, Li, Jun, Hu, Xin, Mehran, Reza, Rice, David, Swisher, Stephen, Sepesi, Boris, Tran, Hai, Chow, Chi-Wan, Little, Latasha, Gumbs, Curtis, Haymaker, Cara, Heymach, John, Wistuba, Ignacio, Lee, J. Jack, Futreal, P. Andrew, Zhang, Jianhua, Reuben, Alexandre, Tsao, Anne, Zhang, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709879/
https://ncbi.nlm.nih.gov/pubmed/32816946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1767
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