Evolution of genomic and T cell repertoire heterogeneity of malignant pleural mesothelioma under dasatinib treatment

PURPOSE: Malignant pleural mesothelioma (MPM) is considered an orphan disease with few treatment options. Despite multimodality therapy, the majority of MPM recur and eventually become refractory to any systemic treatment. One potential mechanism underlying therapeutic resistance may be intratumor h...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Chen, Runzhe, Lee, Won-Chul, Fujimoto, Junya, Li, Jun, Hu, Xin, Mehran, Reza, Rice, David, Swisher, Stephen, Sepesi, Boris, Tran, Hai, Chow, Chi-Wan, Little, Latasha, Gumbs, Curtis, Haymaker, Cara, Heymach, John, Wistuba, Ignacio, Lee, J. Jack, Futreal, P. Andrew, Zhang, Jianhua, Reuben, Alexandre, Tsao, Anne, Zhang, Jianjun
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709879/
https://ncbi.nlm.nih.gov/pubmed/32816946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1767
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