Elevated PDGFRB gene copy number gain (CNG) is prognostic for improved survival outcomes in resected malignant pleural mesothelioma

BACKGROUND: PDGF/PDGFR pathway has been implicated in malignant pleural mesothelioma (MPM) carcinogenesis and evidence suggests autocrine mechanisms of proliferation. We sought to evaluate the incidence of PDGFRB gene copy number gain (CNG) by fluorescence in situ hybridization (FISH) and PDGFR path...

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Detalhes bibliográficos
Main Authors: Tsao, Anne S., Harun, Nusrat, Fujimoto, Junya, Devito, Vikki, Lee, J. Jack, Kuhn, Elisabetta, Mehran, Reza, Rice, David, Moran, Cesar, Hong, Waun Ki, Shen, Li, Suraokar, Milind, Wistuba, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136493/
https://ncbi.nlm.nih.gov/pubmed/24747001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.anndiagpath.2014.02.005
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