Elevated PDGFRB gene copy number gain (CNG) is prognostic for improved survival outcomes in resected malignant pleural mesothelioma

BACKGROUND: PDGF/PDGFR pathway has been implicated in malignant pleural mesothelioma (MPM) carcinogenesis and evidence suggests autocrine mechanisms of proliferation. We sought to evaluate the incidence of PDGFRB gene copy number gain (CNG) by fluorescence in situ hybridization (FISH) and PDGFR path...

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Bibliografiska uppgifter
Huvudupphovsmän: Tsao, Anne S., Harun, Nusrat, Fujimoto, Junya, Devito, Vikki, Lee, J. Jack, Kuhn, Elisabetta, Mehran, Reza, Rice, David, Moran, Cesar, Hong, Waun Ki, Shen, Li, Suraokar, Milind, Wistuba, Ignacio
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136493/
https://ncbi.nlm.nih.gov/pubmed/24747001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.anndiagpath.2014.02.005
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