Elevated PDGFRB gene copy number gain (CNG) is prognostic for improved survival outcomes in resected malignant pleural mesothelioma

BACKGROUND: PDGF/PDGFR pathway has been implicated in malignant pleural mesothelioma (MPM) carcinogenesis and evidence suggests autocrine mechanisms of proliferation. We sought to evaluate the incidence of PDGFRB gene copy number gain (CNG) by fluorescence in situ hybridization (FISH) and PDGFR path...

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Main Authors: Tsao, Anne S., Harun, Nusrat, Fujimoto, Junya, Devito, Vikki, Lee, J. Jack, Kuhn, Elisabetta, Mehran, Reza, Rice, David, Moran, Cesar, Hong, Waun Ki, Shen, Li, Suraokar, Milind, Wistuba, Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136493/
https://ncbi.nlm.nih.gov/pubmed/24747001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.anndiagpath.2014.02.005
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