TCR repertoire intratumor heterogeneity in localized lung adenocarcinomas: an association with predicted neoantigen heterogeneity and postsurgical recurrence

Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens were shown to alter tumor immunogenicity through T cell responses. Here, we performed sequencing of the T cell receptor (TCR) i...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Reuben, Alexandre, Gittelman, Rachel, Gao, Jianjun, Zhang, Jiexin, Yusko, Erik C., Wu, Chang-Jiun, Emerson, Ryan, Zhang, Jianhua, Tipton, Christopher, Li, Jun, Quek, Kelly, Gopalakrishnan, Vancheswaran, Chen, Runzhe, Vence, Luis M., Cascone, Tina, Vignali, Marissa, Fujimoto, Junya, Rodriguez-Canales, Jaime, Parra, Edwin R., Little, Latasha D., Gumbs, Curtis, Forget, Marie-Andrée, Federico, Lorenzo, Haymaker, Cara, Behrens, Carmen, Benzeno, Sharon, Bernatchez, Chantale, Sepesi, Boris, Gibbons, Don L., Wargo, Jennifer A., William, William N., Swisher, Stephen, Heymach, John V., Robins, Harlan, Lee, J. Jack, Sharma, Padmanee, Allison, James P., Futreal, P. Andrew, Wistuba, Ignacio I., Zhang, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628137/
https://ncbi.nlm.nih.gov/pubmed/28733428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0256
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