TCR repertoire intratumor heterogeneity in localized lung adenocarcinomas: an association with predicted neoantigen heterogeneity and postsurgical recurrence

Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens were shown to alter tumor immunogenicity through T cell responses. Here, we performed sequencing of the T cell receptor (TCR) i...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Reuben, Alexandre, Gittelman, Rachel, Gao, Jianjun, Zhang, Jiexin, Yusko, Erik C., Wu, Chang-Jiun, Emerson, Ryan, Zhang, Jianhua, Tipton, Christopher, Li, Jun, Quek, Kelly, Gopalakrishnan, Vancheswaran, Chen, Runzhe, Vence, Luis M., Cascone, Tina, Vignali, Marissa, Fujimoto, Junya, Rodriguez-Canales, Jaime, Parra, Edwin R., Little, Latasha D., Gumbs, Curtis, Forget, Marie-Andrée, Federico, Lorenzo, Haymaker, Cara, Behrens, Carmen, Benzeno, Sharon, Bernatchez, Chantale, Sepesi, Boris, Gibbons, Don L., Wargo, Jennifer A., William, William N., Swisher, Stephen, Heymach, John V., Robins, Harlan, Lee, J. Jack, Sharma, Padmanee, Allison, James P., Futreal, P. Andrew, Wistuba, Ignacio I., Zhang, Jianjun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628137/
https://ncbi.nlm.nih.gov/pubmed/28733428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0256
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