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Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir
Abacavir (ABC) is a guanosine nucleoside reverse transcriptase inhibitor (NRTI) with potent antiretroviral activity. Since NRTIs exhibit tissue-specific inhibition of mitochondrial DNA (mtDNA) synthesis, the ability of ABC to inhibit mtDNA synthesis in vivo was evaluated. Inbred wild-type (WT) and t...
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| Izdano u: | Cardiovasc Toxicol |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704124/ https://ncbi.nlm.nih.gov/pubmed/20379802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-010-9070-2 |
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