Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy

Transgenic mice (TG) were used to define mitochondrial oxidative stress and cardiomyopathy (CM) induced by zidovudine (AZT), an antiretroviral used to treat HIV/AIDS. Genetically engineered mice either depleted or overexpressed mitochondrial superoxide dismutase (SOD2(+/−) KOs and SOD2-OX, respectiv...

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Pubblicato in:Lab Invest
Autori principali: Kohler, James J, Cucoranu, Ioan, Fields, Earl, Green, Elgin, He, Stanley, Hoying, Amy, Russ, Rodney, Abuin, Allison, Johnson, David, Hosseini, Seyed H, Raper, C Michael, Lewis, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7712498/
https://ncbi.nlm.nih.gov/pubmed/19398959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.39
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