Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation

Mitochondrial toxicity results from pyrimidine nucleoside reverse transcriptase inhibitors (NRTIs) for HIV/AIDS. In the heart, this can deplete mitochondrial (mt) DNA and cause cardiac dysfunction (eg, left ventricle hypertrophy, LVH). Four unique transgenic, cardiac-targeted overexpressors (TGs) we...

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Detalhes bibliográficos
Main Authors: Kohler, James J, Hosseini, Seyed H, Cucoranu, Ioan, Hoying-Brandt, Amy, Green, Elgin, Johnson, David, Wittich, Bree, Srivastava, Jaya, Ivey, Kristopher, Fields, Earl, Russ, Rodney, Raper, C Michael, Santoianni, Robert, Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685200/
https://ncbi.nlm.nih.gov/pubmed/19079325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2008.121
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