Targeted Transgenic Overexpression of Mitochondrial Thymidine Kinase (TK2) Alters Mitochondrial DNA (mtDNA) and Mitochondrial Polypeptide Abundance : Transgenic TK2, mtDNA, and Antiretrovirals

Mitochondrial toxicity limits nucleoside reverse transcriptase inhibitors (NRTIs) for acquired immune deficiency syndrome. NRTI triphosphates, the active moieties, inhibit human immunodeficiency virus reverse transcriptase and eukaryotic mitochondrial DNA polymerase pol-γ. NRTI phosphorylation seems...

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Hlavní autoři: Hosseini, Seyed H., Kohler, James J., Haase, Chad P., Tioleco, Nina, Stuart, Tami, Keebaugh, Erin, Ludaway, Tomika, Russ, Rodney, Green, Elgin, Long, Robert, Wang, Liya, Eriksson, Staffan, Lewis, William
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864875/
https://ncbi.nlm.nih.gov/pubmed/17322372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060655
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