Targeted Transgenic Overexpression of Mitochondrial Thymidine Kinase (TK2) Alters Mitochondrial DNA (mtDNA) and Mitochondrial Polypeptide Abundance : Transgenic TK2, mtDNA, and Antiretrovirals

Mitochondrial toxicity limits nucleoside reverse transcriptase inhibitors (NRTIs) for acquired immune deficiency syndrome. NRTI triphosphates, the active moieties, inhibit human immunodeficiency virus reverse transcriptase and eukaryotic mitochondrial DNA polymerase pol-γ. NRTI phosphorylation seems...

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Detalhes bibliográficos
Main Authors: Hosseini, Seyed H., Kohler, James J., Haase, Chad P., Tioleco, Nina, Stuart, Tami, Keebaugh, Erin, Ludaway, Tomika, Russ, Rodney, Green, Elgin, Long, Robert, Wang, Liya, Eriksson, Staffan, Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864875/
https://ncbi.nlm.nih.gov/pubmed/17322372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060655
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