Targeted Transgenic Overexpression of Mitochondrial Thymidine Kinase (TK2) Alters Mitochondrial DNA (mtDNA) and Mitochondrial Polypeptide Abundance : Transgenic TK2, mtDNA, and Antiretrovirals

Mitochondrial toxicity limits nucleoside reverse transcriptase inhibitors (NRTIs) for acquired immune deficiency syndrome. NRTI triphosphates, the active moieties, inhibit human immunodeficiency virus reverse transcriptase and eukaryotic mitochondrial DNA polymerase pol-γ. NRTI phosphorylation seems...

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Detaylı Bibliyografya
Asıl Yazarlar: Hosseini, Seyed H., Kohler, James J., Haase, Chad P., Tioleco, Nina, Stuart, Tami, Keebaugh, Erin, Ludaway, Tomika, Russ, Rodney, Green, Elgin, Long, Robert, Wang, Liya, Eriksson, Staffan, Lewis, William
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2007
Konular:
Regular Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864875/
https://ncbi.nlm.nih.gov/pubmed/17322372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060655
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