DECREASED mtDNA, OXIDATIVE STRESS, CARDIOMYOPATHY, AND DEATH FROM TRANSGENIC CARDIAC TARGETED HUMAN MUTANT POLYMERASE γ *

POLG is the human gene that encodes the catalytic subunit of DNA polymerase γ (Pol γ), the replicase for human mtDNA. A POLG Y955C point mutation causes human chronic progressive external ophthalmoplegia (CPEO), a mitochondrial disease with eye muscle weakness and mtDNA defects. Y955C POLG was targe...

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Hauptverfasser: Lewis, William, Day, Brian J., Kohler, James J., Hosseini, Seyed H., Chan, Sherine S. L., Green, Elgin, Haase, Chad P., Keebaugh, Erin, Long, Robert, Ludaway, Tomika, Russ, Rodney, Steltzer, Jeffrey, Tioleco, Nina, Santoianni, Robert, Copeland, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831462/
https://ncbi.nlm.nih.gov/pubmed/17310215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.3700523
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