Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol γ hypothesis

DESIGN: Nucleoside reverse transcriptase inhibitors (NRTIs) exhibit mitochondrial toxicity. The mitochondrial deoxynucleotide carrier (DNC) transports nucleotide precursors (or phosphorylated NRTIs) into mitochondria for mitochondrial (mt)DNA replication or inhibition of mtDNA replication by NRTIs....

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Autors principals: Lewis, William, Kohler, James J., Hosseini, Seyed H., Haase, Chad P., Copeland, William C., Bienstock, Rachelle J., Ludaway, Tomika, McNaught, Jamie, Russ, Rodney, Stuart, Tami, Santoianni, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779943/
https://ncbi.nlm.nih.gov/pubmed/16514297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.aids.0000216367.23325.58
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