Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol γ hypothesis

DESIGN: Nucleoside reverse transcriptase inhibitors (NRTIs) exhibit mitochondrial toxicity. The mitochondrial deoxynucleotide carrier (DNC) transports nucleotide precursors (or phosphorylated NRTIs) into mitochondria for mitochondrial (mt)DNA replication or inhibition of mtDNA replication by NRTIs....

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Detalhes bibliográficos
Main Authors: Lewis, William, Kohler, James J., Hosseini, Seyed H., Haase, Chad P., Copeland, William C., Bienstock, Rachelle J., Ludaway, Tomika, McNaught, Jamie, Russ, Rodney, Stuart, Tami, Santoianni, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779943/
https://ncbi.nlm.nih.gov/pubmed/16514297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.aids.0000216367.23325.58
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