Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol γ hypothesis

DESIGN: Nucleoside reverse transcriptase inhibitors (NRTIs) exhibit mitochondrial toxicity. The mitochondrial deoxynucleotide carrier (DNC) transports nucleotide precursors (or phosphorylated NRTIs) into mitochondria for mitochondrial (mt)DNA replication or inhibition of mtDNA replication by NRTIs....

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Auteurs principaux: Lewis, William, Kohler, James J., Hosseini, Seyed H., Haase, Chad P., Copeland, William C., Bienstock, Rachelle J., Ludaway, Tomika, McNaught, Jamie, Russ, Rodney, Stuart, Tami, Santoianni, Robert
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779943/
https://ncbi.nlm.nih.gov/pubmed/16514297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.aids.0000216367.23325.58
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