Cardiac-Targeted Transgenic Mutant Mitochondrial Enzymes: mtDNA Defects, Antiretroviral Toxicity and Cardiomyopathy

Mitochondrial (mt) DNA biogenesis is critical to cardiac contractility. DNA polymerase gamma (pol γ) replicates mtDNA, whereas thymidine kinase 2 (TK2) monophosphorylates pyrimidines intramitochondrially. Point mutations in POLG and TK2 result in clinical diseases associated with mtDNA depletion and...

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Main Authors: Kohler, James J., Hosseini, Seyed H., Green, Elgin, Hoying-Brandt, Amy, Cucoranu, Ioan, Haase, Chad P., Russ, Rodney, Srivastava, Jaya, Ivey, Kristopher, Ludaway, Tomika, Kapoor, Victor, Abuin, Allison, Shapoval, Alexsey, Santoianni, Robert, Saada, Ann, Elpeleg, Orly, Lewis, William
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701312/
https://ncbi.nlm.nih.gov/pubmed/18446447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-008-9015-1
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