Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir

Abacavir (ABC) is a guanosine nucleoside reverse transcriptase inhibitor (NRTI) with potent antiretroviral activity. Since NRTIs exhibit tissue-specific inhibition of mitochondrial DNA (mtDNA) synthesis, the ability of ABC to inhibit mtDNA synthesis in vivo was evaluated. Inbred wild-type (WT) and t...

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Detalhes bibliográficos
Publicado no:Cardiovasc Toxicol
Main Authors: Kohler, James J., Hosseini, Seyed H., Green, Elgin, Fields, Earl, Abuin, Allison, Ludaway, Tomika, Russ, Rodney, Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704124/
https://ncbi.nlm.nih.gov/pubmed/20379802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-010-9070-2
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