AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress

Mitochondrial dysfunction causes oxidative stress and cardiomyopathy. Oxidative stress also is a side effect of dideoxynucleoside antiretrovirals (NRTI) and is observed in NRTI-induced cardiomyopathy. We show here that treatment with the NRTI AZT {1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-...

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Detalhes bibliográficos
Publicado no:Physiol Genomics
Main Authors: Koczor, Christopher A., Jiao, Zhe, Fields, Earl, Russ, Rodney, Ludaway, Tomika, Lewis, William
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Call for Papers: Epigenetics and Epigenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593827/
https://ncbi.nlm.nih.gov/pubmed/26199398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00045.2015
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