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Transgenic Mouse Model with Deficient Mitochondrial Polymerase Exhibits Reduced State IV Respiration and Enhanced Cardiac Fibrosis
Mitochondria produce the energy required for proper cardiac contractile function, and cardiomyocytes that exhibit reduced mitochondrial electron transport will have reduced energy production and decreased contractility. Mitochondrial DNA (mtDNA) encodes the core subunits for the protein complexes of...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3556371/ https://ncbi.nlm.nih.gov/pubmed/23090637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.146 |
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