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Transgenic Mouse Model with Deficient Mitochondrial Polymerase Exhibits Reduced State IV Respiration and Enhanced Cardiac Fibrosis

Mitochondria produce the energy required for proper cardiac contractile function, and cardiomyocytes that exhibit reduced mitochondrial electron transport will have reduced energy production and decreased contractility. Mitochondrial DNA (mtDNA) encodes the core subunits for the protein complexes of...

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Bibliografske podrobnosti
Main Authors:	Koczor, Christopher A., Torres, Rebecca A., Fields, Earl, Qin, Qianhong, Park, Jade, Ludaway, Tomika, Russ, Rodney, Lewis, William
Format:	Artigo
Jezik:	Inglês
Izdano:	2012
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3556371/ https://ncbi.nlm.nih.gov/pubmed/23090637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.146
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Transgenic Mouse Model with Deficient Mitochondrial Polymerase Exhibits Reduced State IV Respiration and Enhanced Cardiac Fibrosis

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