Transgenic Mouse Model with Deficient Mitochondrial Polymerase Exhibits Reduced State IV Respiration and Enhanced Cardiac Fibrosis

Mitochondria produce the energy required for proper cardiac contractile function, and cardiomyocytes that exhibit reduced mitochondrial electron transport will have reduced energy production and decreased contractility. Mitochondrial DNA (mtDNA) encodes the core subunits for the protein complexes of...

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Hlavní autoři: Koczor, Christopher A., Torres, Rebecca A., Fields, Earl, Qin, Qianhong, Park, Jade, Ludaway, Tomika, Russ, Rodney, Lewis, William
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556371/
https://ncbi.nlm.nih.gov/pubmed/23090637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.146
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