Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

Cardiac hypertrophy is a well-known major risk factor for poor prognosis in patients with cardiovascular diseases. Dysregulation of intracellular Ca(2+) is involved in the pathogenesis of cardiac hypertrophy. However, the precise mechanism underlying cardiac hypertrophy remains elusive. Here, we inv...

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Pubblicato in:Commun Biol
Autori principali: Kohno, Michiaki, Kobayashi, Shigeki, Yamamoto, Takeshi, Yoshitomi, Ryosuke, Kajii, Toshiro, Fujii, Shohei, Nakamura, Yoshihide, Kato, Takayoshi, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Watanabe, Kenji, Mizukami, Yoichi, Yano, Masafumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691336/
https://ncbi.nlm.nih.gov/pubmed/33244105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01443-w
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