EXTH-51. ANTI-INVASIVE EFFICACY AND SURVIVAL BENEFIT OF THE YAP-TEAD INHIBITOR VERTEPORFIN IN PRECLINICAL GLIOBLASTOMA MODELS

Glioblastoma (GBM) remains an incurable disease, in large part due to its malignant infiltrative spread, and current clinical therapy fails to target the invasive nature of tumor cells in disease progression and recurrence. Here, we use the YAP-TEAD inhibitor Verteporfin to target a convergence poin...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Barrette, Anne Marie, Bouras, Alexandros, Nudelman, German, Mussa, Zarmeen, Zaslavsky, Elena, Hadjipanayis, Constantinos, Birtwistle, Marc, Tsankova, Nadejda
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.405
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