EXTH-51. ANTI-INVASIVE EFFICACY AND SURVIVAL BENEFIT OF THE YAP-TEAD INHIBITOR VERTEPORFIN IN PRECLINICAL GLIOBLASTOMA MODELS

Glioblastoma (GBM) remains an incurable disease, in large part due to its malignant infiltrative spread, and current clinical therapy fails to target the invasive nature of tumor cells in disease progression and recurrence. Here, we use the YAP-TEAD inhibitor Verteporfin to target a convergence poin...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Barrette, Anne Marie, Bouras, Alexandros, Nudelman, German, Mussa, Zarmeen, Zaslavsky, Elena, Hadjipanayis, Constantinos, Birtwistle, Marc, Tsankova, Nadejda
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Preclinical Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.405
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