EXTH-27. YAP/TAZ TRANSCRIPTIONAL CO-ACTIVATORS CREATE THERAPEUTIC VULNERABILITY TO VERTEPORFIN IN EGFR MUTANT GLIOBLASTOMA

Glioblastoma (GBM), neoplasms derived from glia and neuro-glial stem/progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months with current treatments. GBM tumorigenicity is often driven by genetic aberrations in receptor...

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Publicado en:Neuro Oncol
Autores principales: Read, Renee, Vigneswaran, Krishanthan, Boyd, Nathaniel, Oh, Se-Yeong, Lallani, Shoeb, Boucher, Andrew, Neill, Stewart, Olson, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Preclinical Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651392/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.381
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