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OS1.6 Characterizing the Over-expression of Yki/YAP/TAZ Transcription Factors in Gliomagenesis and Results of a Phase 0 Clinical Trial for a Proposed Novel Treatment of Glioblastomas
BACKGROUND: Glioblastomas (GBMs) harbor frequent genetic lesions that include amplification, mutation, and/or over expression of receptor tyrosine kinases (RTKs). Using a novel kinome wide RNAi screen we identified the Hippo kinase pathway and it downstream targets, Yki-YAP/TAZ transcription factors...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6144077/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.012 |
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